The Lifelines cohort study has an open protocol. On the one hand, this means that a fixed protocol is observed to follow study participants over time. On the other hand, it offers researchers the opportunity to collect additional data and/or biological samples within the existing infrastructure. To this end, researchers can submit an application for an additional study. This allows them to obtain an additional questionnaire or collect additional samples among a group of participants. Please contact the Lifelines Research Office for more information on the possibilities of an additional study.
Below you can find a few of the very successful additional studies that have been or are being conducted within the Lifelines cohort. If you would like to know more about the studies below, or have a question regarding access to data and samples, please contact the Lifelines Research Office.
Previously we collected additional data and biological samples in 1500 Lifelines participants to allow for new insights into disease mechanisms and prevention. In the subsequent study DAG3 we scaled up the number of participants as well as the number of microbiome sample sites. We enclosed 10,000 Lifelines participants and collected upon the regular collected biological samples: PAXgene blood, microbiome samples from feces , throat, tongue and nose for among others sequencing and culturing. The “LifeLines DAG3” cohort is a truly unique cohort of extremely well phenotyped Dutch individuals that can help address many different scientific questions.
measurement of cortisol in scalp hair using LC-MS/MS: determination of a reference range and evaluation of hair sample collection in the Lifeines cohort study
The aim of this study is to create reference values for cortisol in scalp hair, obtained through a new measurement technique using LC-MS/MS. Furthermore, it is examined whether the associations between hair cortisol and waist circumference, BMI and metabolic parameters that were found using immunoassays can be confirmed using LC-MS/MS. Additionally, these results can be used to evaluate the protocol of hair collection in Lifelines in a pilot setting.