Publication: AGEs are associated with physical activity and physical functioning in the older population


Researchers: Drenth H, Zuidema SU, Krijnen WP, Bautmans I, Hobbelen H, et al.


Decline in physical activity and functioning is commonly observed in the older population and might be associated with biomarkers such as Advanced Glycation End-products (AGEs). AGEs contribute to age-related decline in the function of cells and tissues in normal aging and have been found to be associated with motor function decline. The aim of this study was to investigate the association between the levels of AGEs, as assessed by skin autofluorescence, and the amount of physical activity and loss of physical functioning in older participants.


This study indicated that high AGE levels may be a contributing factor as well as a biomarker for lower levels of physical activity and functioning in the older population.