To facilitate research on healthy ageing, genomic data is very relevant. We have collected and analysed SNP data, gut microbiome data and whole genome sequence data. Currently available via Lifelines are GWAS SNP data. Other datasets are either available through a collaborating partner or data collection is still ongoing, e.g. methylation profiles and RNAseq data. For a specific request and to learn about the possibilities, please feel free to contact us.
Genome-wide genotype data was collected using the Illumina CytoSNP-12v2 array. Currently SNP data from this array are available for ~15,000 participants. All GWAS participants are independent adults (18 years and older) and have Caucasianancestry. The CytoSNP-12v2 array contains approximately 200,000 SNPs targeting regions. SNP data obtained from the array were used to map against human reference genomes, i.e. the Genome of The Netherlands (GoNL) release 5 and the 1000 Genomes phase1 v3 reference panels. By mapping the SNPs generated by the array against these reference genomes, more SNPs, that were not on the array, can be imputed.
Expansion of genomic data UGLI
An additional 38,000 participants are currently being genotyped using the Illumina global screening array (GSA) Beadchip-24 v1.0 (Caucasian-ancestry samples of adults 18 years and older and ~3,000 children aged 8-17). This array contains approximately 1,000,000 SNPs and combines multi-ethnic genome-wide content, curated clinical research variants and quality control (QC) markers for precision medicine research. All genotypes obtained from the array will be mapped against the global Haplotype Reference Consortium (HRC) panel to impute more SNPs. UGLI data is currently being generated, analysed and quality checked. This data will be available soon. If you are interested in the UGLI data please contact us.
How to apply for genomic data
If your application (also) concerned genotype data, you will have access to this data via a secure link to a High-Performance Computing (HPC) cluster from the Workspace. The cluster is equipped with the common programs for genotype data analysis. Read more about using the HPC cluster (download).